![]() ![]() Some of these forms, such as membranes, gels and hydrogels, nanoparticles, and scaffolds, can be effective in drug delivery with controlled release of active elements with antimicrobial actions, avoiding infections and accelerating healing. Therefore, chitosan can be easily processed into a variety of forms to treat skin lesions. However, the efficacy of its properties depends strictly on molecular weight, degree of deacetylation, polydispersibility, and its structure. The chemical modifications of chitosan are associated with a tendency for changes caused by the hydroxyl and amine functional groups present in its structure. Ĭhitosan is composed of units of poly-(beta-1-4) N-acetyl- d-glucosamine, extracted through partial deacetylation of chitin, one of the most abundant renewable biopolymers, which is obtained at low cost and on a large scale through marine sources. In addition, chitosan acts actively as a hemostatic agent and supports tissue regeneration, and is therefore beneficial in wound healing. Chitosan’s numerous essential advantages are related to its interaction with the tissue, causing no or low toxicity to degradation, as well as having anti-inflammatory and antibacterial effects. Chitosan is a natural cationic biopolymer and has been considered in various biomedical applications, including wound healing, because of its many biological and physical-chemical attributes suitable for application in dressings. īiopolymers materials, for example, are commonly used in the medical field as dressings, wound treatment, drug delivery, tissue engineering, and medical implants. In addition to these attributes, researchers are currently searching for dressing covers that interact with the wound and release natural bioactive molecules that provide elements necessary for wound healing. Moreover, it must stimulate growth factors, promote tissue granulation and reepithelization, and be easy to remove. ![]() For efficient wound healing, it is necessary that the dressing is non-allergenic, non-toxic, maintains moisture, allows gas exchanges, protects the wound against pathogenic microorganisms, and absorbs exudates from the wound. Innovative dressings have been targeted by researchers to assist in the regeneration of damaged tissues. However, biological studies are necessary for the safe use of chitosan/copaiba oil membrane as a biomaterial. Such characteristics are expected to favor wound treatment. In addition, the copaiba oil modified the crystalline structure of chitosan. The highest fluid absorption indexes were observed in chitosan membranes containing 0.1 and 0.5% ( v/ v) of copaiba oil. In addition, the results showed that chitosan membranes with the addition of 1.0% (v/ v) of copaiba oil presented oil drops with larger diameters, around 123.78 μm. These chitosan/copaiba oil porous membranes disclosed fluid absorption capacity, hydrophilic surface, and moisture. The membranes were developed by the casting method and analyzed for their morphology, degree of intumescence, moisture content, contact angle, Scanning Electron Microscope, and X-ray diffractometry. In the present work, chitosan membranes containing different contents of copaiba oil copaíba (0.1, 0.5, 1.0 and 5.0% ( v/ v)) were for the first time investigated. Indeed, the bioactive principles present in copaiba oil have anti-inflammatory and healing action. ![]() The interaction of copaiba oil in the polymer matrix of chitosan can produce a favorable synergistic effect and potentiate properties. ![]()
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